The way a bone grafting technology works depends on many factors including the properties of the graft itself. The novel i-FACTOR Bone Graft “ Attract, Attach, Activate” mechanism of action enhances the body’s natural bone healing process. The high affinity between cells and P-15 supports the physiological mechanism of action in which cells bind to the P-15 and “turn on” to perform their genetically programmed job of making bone. I-FACTOR Bone Graft facilitates and expedites the ingrowth of bone by promoting the migration of mesenchymal stem cells and other progenitor cells from surrounding tissue. These cells have an affinity for and attach to the P-15 found in i-FACTOR Bone Graft in a similar way they would naturally with Type I collagen in bone. This 15-amino acid peptide (P-15) is responsible for the attachment and proliferation of osteogenic cells. I-FACTOR Bone Graft is based on the biological activity of the synthetically derived 15-amino acid peptide found naturally in Type I human collagen. I-FACTOR™ Bone Graft: Mechanism of Action Introducing donor cells ( osteogenesis).Providing instructions to local cells ( osteoinduction).Providing a scaffold for local cells ( osteoconduction).How the bone graft material responds to these cells is referred to as the mechanism of action. This means that the cells seek out attachment points on the Type I collagen, become attached, and activate the cascade of events leading to bone formation. Many of these connective tissue cells are “ attachment activated“. Practice vishing, try to gain unauthorized access to protected areas, and leave thumb-drives around with suggestive language that would incentivize someone to plug it in.Within tissues are cells that are controlled by and interact with Type I collagen. Set up a phishing engagement that includes more than simple emails with boring links. Here are some suggestions for sprucing things up, in a bid to keep your greatest defense (end-users) active and involved:Īttack your own organization. If your organization tosses together a simple power-point and forces everyone into a 30 minute meeting to go over the same security tropes, the efficacy of that training is reduced. In addition, the type of awareness training is crucial. It would be overly simplistic to suggest user-awareness training alone is the answer, but it is certainly one of the most important cogs. In fact, it’s the premise for politics as a whole. By keeping a potential buyer suspended in a form of anxiety, a sale can be made. Sure, we’re no longer fleeing sabre-tooth tigers, but our brains haven’t caught up yet. Do you know what the difference between a CEO and mail-clerk is? Humans Hate AnxietyĪs with our hard-coded need to trust others, we’re also gifted with the benefit of anxiety. As an example, I’ve successfully pulled C-level executives out of their office and into a conference room with a promise of little more than cake. The trick is exploiting this mechanism to get people to do what they otherwise wouldn’t (or shouldn’t). Being an opportunist doesn’t mean you’re a bad person, it just means your brain quickly calculates risk and reward at lightning speed. Most don’t like to think of themselves as opportunists, but my experiences tell me otherwise. This concept, I suspect, will garnish the most groaning. Sure, it’s a ludicrous notion, but the important part is the reason why it’s ludicrous. The next time you’re driving your vehicle, consciously wonder why the oncoming car doesn’t veer into your lane unpredictably. This means our brains are hard-coded to have a baseline level of trust that is required for survival. Humans are Decent and HelpfulĬulturally, and as a species, we have evolved over millennia because of our ability to think critically, and work together to solve problems. ![]() If you overthink the attack, you’re running the risk of botching it. It’s important to note that the best SE attacks are often the simplest. There are many great resources out there to learn about the mechanisms of an effective SE attack, but I’m going to keep things simple and easy to understand. They’re often shocked and amazed at how easy it is to infiltrate and exfiltrate their organization through lying, cheating, and stealing. When I factor in Social Engineering (SE), their curiosity becomes piqued, and they are almost always left feeling a bit of dread. To most organizations, the work that I perform (penetration testing) is voodoo and heresy. Catch Me If You Can ( DreamWorks Pictures, copyright 2002).
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